Brain SPECT Imaging with Acetazolamide Challenge

Brain SPECT imaging with acetazolamide challenge.

The patient was a 69-y-old man who, 37 d earlier, had a 4-d-long evolving onset of headache, dizziness, acute personality changes, visual changes, and weakness. Unspecified imaging was obtained at an outside facility, and he was diagnosed with an intracerebral stenosis. Subsequently, he was given aspirin and clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership) and told ...

99mTc-HMPAO-SPECT with acetazolamide challenge to detect hemodynamic compromise in occlusive cerebrovascular disease.

BACKGROUND AND PURPOSE Insufficiency of collateral supply may lead to low-flow infarcts in severe occlusive cerebrovascular disease. The aim of this study was to evaluate the feasibility of technetium-99m-labeled hexamethylpropyleneamine oxime (99mTc-HMPAO) single-photon emission computed tomography (SPECT) to assess hemodynamic compromise in the anterior circulation. METHODS Cerebral blood f...

Tc-HMPAO-SPECT With Acetazolamide Challenge to Detect Hemodynamic Compromise in Occlusive Cerebrovascular Disease

Background and Purpose: Insufficiency of collateral supply may lead to low-flow infarcts in severe occlusive cerebrovascular disease. The aim of this study was to evaluate the feasibility of technetium99m-labeled hexamethylpropyleneamine oxime ("Tc-HMPAO) single-photon emission computed tomography (SPECT) to assess hemodynamic compromise in the anterior circulation. Methods: Cerebral blood flow...

Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst.

PURPOSE To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS A 3-D frequency-shifted (FS) burst technique was used to assess the intravascular first pass of contrast agent. Changes in rCBV were calculated in 40 vol...

Absolute quantification in brain SPECT imaging